Journal of Developing Drugs
Open Access
ISSN: 2329-6631
+44 1478 350008
ISSN: 2329-6631
+44 1478 350008
Abbaraju Krishna Sailaja
Associate Professor and Head, RBVRR Women's College of Pharmacy,
Hyderabad
India
Research Article
Preparation and Characterization of Paracetamol Loaded Eudragit S100 Nanoparticles by Salting Out Technique
Author(s): Ayesha Siddiqua Gazi and Abbaraju Krishna SailajaAyesha Siddiqua Gazi and Abbaraju Krishna Sailaja
The aim of this study was to prepare Paracetamol loaded Eudragit S100 nanoparticles by salting out (SO)
technique. Eudragit S100 (ED) was used as a polymer. Paracetamol and polymer were dissolved in ethanol at
various drug-polymer ratios (1:1, 1:2 and 1:3), among three formulations 1:3 was found to be the best formulation
with drug content of 80.3% and entrapment efficiency was found to be 99.8%. Loading capacity was found to be
more for 1:3 formulation. Na.cmc was used as stabilizer and ZnSO4.7H2O was used as a salting out agent and
ethanol were used as solvent. .. View More»
DOI:
10.35248/2329-6631.18.7.183