Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Research Article
A Biochemical Study on the Effects of Fullerene C60 and Fruit Extract of Balanites aegyptica Plant in Ameliorating the Toxicity Induced by Doxorubicin in Streptozotocin Model of Diabetic Male Albino Rats
Author(s): Abd Raheim EL-Shater, Muhammad Salman, Naglaa RA Kasem and Mariam AF MahmoudAbd Raheim EL-Shater, Muhammad Salman, Naglaa RA Kasem and Mariam AF Mahmoud
There were relationship between hyperglycaemic and pharmakinetic of toxicity of doxorubicin that lead to increase oxidative stress on cells. This study was aimed to detect the curative effect of some antioxidants drugs (fullerene C60 and mesocarp fruit extract of Balanites aegyptaica) on the haematological and biochemical of kidney function parameters after induced by diabetes and toxicity with doxorubicin on the rats. Nine groups of adult male albino rats were established (n=8). The first group (Group 1) was served as normal group. Group 2 was injected intraperitoneal (i.p) with by streptozotocin at single dose (45 mg/kg body weight). Diabetic rats (Group 3) were injected intraperitoneal (i.p) with doxorubicin at dose (5 mg/kg body weight) for three days. Diabetic rats (Group 4) were given orally fullerene C60 daily at dose (4 mg/kg body weight). Diabet.. View More»
DOI:
10.4172/2161-0495.1000404