Medicinal & Aromatic Plants
Open Access

Abdel Nasser B Singab

Publications

• Research Article
  Hepatoprotective, Antihyperglycemic and Cytotoxic Activities of Jacaranda acutifolia Leaf Extract
  Author(s): Nada M Mostafa, Omayma A Eldahshan, Hesham A El-Beshbishy and Abdel Nasser B Singab Nada M Mostafa, Omayma A Eldahshan, Hesham A El-Beshbishy and Abdel Nasser B Singab
  
  Objective: Leaves methanol extract of Jacaranda acutifolia Humb. and Bonpl. (JA) family Bignoniaceae was subjected to phytochemical investigation as well as antioxidant, hepatoprotective, cytotoxic and antihyperglycemic activities evaluation. Key findings: Eight compounds were identified: luteolin-7-O-β-D-glucuronide, luteolin-7-O-β-D-glucoside, aesculetin, luteolin, verbascoside, luteolin-7-O-β-D-glucuronide methyl ester, apigenin-7-O-β-D-glucuronide methyl ester and apigenin. JA revealed a potent antioxidant activity In vitro superior to vitamin E (DPPH assay; EC50 of 0.43 mg/mL). A potential cytotoxic activity was produced against hepatocellular (HepG2) and cervical (HeLa) carcinoma cells with IC50 of 6.05 and 16.7 μg, respectively. Treatment with JA extract inhibited the rise in alanine aminotransferase and asparta.. View More»
  DOI: 10.4172/2167-0412.1000297

  Abstract PDF

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