ISSN: 2161-0932
Abdelghafar S Dawood
Egypt
Research Article
Reduction of Postoperative Adhesions after Laparoscopic Surgery for Endometriosis by Using a Novel Anti-Fibrotic Drug Pirfenidone: A Randomized Double Blind Study
Author(s): Ahmed S El-Halwagy, Adel A Al-Gergawy, Abdelghafar S Dawood and Ayman ShehataAhmed S El-Halwagy, Adel A Al-Gergawy, Abdelghafar S Dawood and Ayman Shehata
Introduction: This study was done to insight the effect of the novel anti-fibrotic drug Pirfenidone in the prevention of postoperative endometriosis induced adhesions.
Patients and methods: 210 patients were enrolled and randomly allocated into 2 groups according to sequence of computer-generated block-random numbers. Each group included 105 patients. This prospective randomized double blind controlled study was conducted at Tanta University Hospital between August 2013 and May 2016. In group A (study group) the patients after the initial laparoscopic management received Pirfenidone 200 mg (pirfinex) tablets in a dose of 3 tablets tds i.e. 1800 mg daily for 6 months while in group B (control group) the patients after the initial laparoscopy received placebo starch tablets 3 tablets tds also for 6 months.
The patients in both study grou.. View More»
DOI:
10.4172/2161-0932.1000422