Journal of Hematology & Thromboembolic Diseases
Open Access

Abdessamed Arabi

Publications

• Research Article
  Efficacy of L-Asparaginase Combination Therapy in Localized Extranodal NK/T-Cell Lymphoma: A Single Institution Experience
  Author(s): Mohamed Amine Bekadja, Samira Bouchama, Leila Charef1, Nabil Yafour, Badra Entasoltan, Abdessamed Arabi, Rachid Bouhass1 and Mohamed BrahimiMohamed Amine Bekadja, Samira Bouchama, Leila Charef1, Nabil Yafour, Badra Entasoltan, Abdessamed Arabi, Rachid Bouhass1 and Mohamed Brahimi
  
  Background: Nasal extranodal natural killer (NK)/T-cell lymphoma are highly aggressive diseases with a poor outcome. Several studies have shown the interest of L-asparaginase in salvage therapy and first-line L-asparaginase combination therapy for advanced stage extranodal NK/T-cell lymphoma should be tested in prospective trials. We report the first experience of treatment with L-asparaginase in salvage therapy and front-line based- regimen in localized nasal NK/T-cell lymphoma. Patients and methods: We reviewed 13 consecutive localized stages I/II nasal NK/T cell lymphomas, treated in our institution over a 6 years period. 8 patients were treated with CHOP (cyclophosphamide, doxorubicin, oncovin and prednisone) regimen in first-line chemotherapy and with L-asparaginase-based regimen in salvage therapy. Five patients were treated with first-l.. View More»
  DOI: 10.4172/2329-8790.1000109

  Abstract PDF

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