Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Abdul Halim Abdul Gafor
Malaysia
Research Article
Urine Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in Lupus Nephritis: A Prospective Longitudinal Study
Author(s): Sabah Alharazy, Norella CT Kong, Marlyn Mohd, Shamsul A Shah, Arbaiyah Ba´in and Abdul Halim Abdul GaforSabah Alharazy, Norella CT Kong, Marlyn Mohd, Shamsul A Shah, Arbaiyah Ba´in and Abdul Halim Abdul Gafor
Objective: Urine neutrophil gelatinase-associated lipocalin (uNGAL) is increased in active lupus nephritis (LN). In this longitudinal study, we further evaluated the role of uNGAL as a potential marker for monitoring LN response to treatment and/or early relapse.Methods: uNGAL levels were measured at baseline and at 2- and 4-months in 100 patients with biopsy-proven LN. They were divided into 2 groups - active LN [non-remission (NR) and relapses] and inactive LN [complete remission (CR) or partial remission (PR)]. Renal function test, urinary parameters, lupus serology and renal SLE disease activity index-2K (renal SLEDAI-2K) were analyzed to determine their associations with uNGAL.Results: At baseline, there were 47 patients in the active group (42 NR and 5 relapsed) and 53 in the inactive group (51 CR and 2 PR). With tre.. View More»
DOI:
10.4172/2155-9899.1000214