Journal of Applied Pharmacy
Open Access

Abdulrahman S Alanazi

Publications

• Research Article
  Hypoglycemic and Antioxidant Effect of Morus alba L. Stem Bark Extracts in Streptozotocin-Induced Diabetes in Rats
  Author(s): Abdulrahman S Alanazi, Md Jamir Anwar and Md Niyaz AlamAbdulrahman S Alanazi, Md Jamir Anwar and Md Niyaz Alam
  
  The present study aims to evaluate the antidiabetic effect of Morus alba L. stem bark extract in experimental model of diabetes. The animals were divided into six groups as: control group (I); pathogenic control group (II) injected intravenously (i.v.) with single dose of STZ (60 mg/kg); morus alba stem bark extract (group-III; 200 mg/kg), and group-IV (400 mg/kg); group-V animals treated with glibenclamide (5 mg/kg, p.o.) following STZ treatment; group-VI, animals treated with bark extract per se (400 mg/kg). The results of this study showed a significant increase in lipid peroxidation, blood glucose level, glycosylated heamoglobin level, and reduction in glutathione and insulin level after STZ administration. These parameters were significantly (p<0.05) reversed by extracts dose dependently. The biochemical findings were also supported by histopathological studies of pancreas whe.. View More»
  DOI: 10.21065/1920-4159.1000234

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