Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Abhishek Trigunaite
Tanzania
Review Article
Pro- and Anti-inflammatory Neutrophils in Lupus
Author(s): Evan Der, Abhishek Trigunaite, Ayesha Khan and Trine N. Jorgensen
Evan Der, Abhishek Trigunaite, Ayesha Khan and Trine N. Jorgensen
A hallmark of SLE is the presence of elevated levels of circulating anti-nuclear autoantibodies specific towards chromatin, histones or dsDNA. Understanding the regulation of antibody production is therefore of utmost importance in understanding lupus pathogenesis. Spearheaded by the identification of accumulating immunosuppressive neutrophils in cancer patients, the nature and function of neutrophils have expanded from a uniform pro-inflammatory cell population to a heterogeneous population of cells with pro-inflammatory or immunosuppressive capacities. While much is known about pro-inflammatory neutrophils and the likely pathogenic function of such cells in lupus, a potential role for immunosuppressive neutrophils in protecting genetically predisposed individuals has only recently emerged. For example, SLE-derived neutrophils spontaneously produce type I interferons (IFNα), st.. View More»
DOI:
10.4172/2155-9899.1000239