Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Adegbegi J Ademuyiwa
Department of Science Laboratory Technology, Rufus Giwa Polytechnic, Owo, Ondo State,
Nigeria
Research Article
Protective Effects of Cyclohexyl methyl dithiocarbamates Sodium Salts on Diclofenac Induced Reproductive Toxicity in Male Albino Rats
Author(s): Adegbegi J Ademuyiwa, Jose R Adeolu and Adefegha S AdeniyiAdegbegi J Ademuyiwa, Jose R Adeolu and Adefegha S Adeniyi
The present study investigates the effect of cyclohexylmethyldithiocarbamates sodium salt (a synthetic compound) and vitamin E against diclofenac-induced blood and testes of experimental Wistar male albino rats. The study consists of six groups of six rats each. Group I (control) received corn oil (3 ml/kg b.w), Group II received diclofenac (100 mg/kg b.w), Group III rats were treated with diclofenac and cyclohexylmethyldithiocarbamates sodium salt (30 mg/kg b.w), Group IV was administered diclofenac and Vitamin E (30 mg/kg b.w), Group V was given cyclohexylmethyldithiocarbamates sodium salt (30 mg/kg b.w) only and Group VI received vitamin E only. The results showed a significant (p<0.05) decrease in the daily sperm production in the diclofenac only treated rats, diclofenac with Na (HxMedtc), diclofenac with vitamin E treated rats and Na (HxMedtc) treated rats but no significant (.. View More»
DOI:
10.4172/2167-0501.1000155