Biochemistry & Pharmacology: Open Access
Open Access

Adegbegi J Ademuyiwa

Publications

• Research Article
  Protective Effects of Cyclohexyl methyl dithiocarbamates Sodium Salts on Diclofenac Induced Reproductive Toxicity in Male Albino Rats
  Author(s): Adegbegi J Ademuyiwa, Jose R Adeolu and Adefegha S AdeniyiAdegbegi J Ademuyiwa, Jose R Adeolu and Adefegha S Adeniyi
  
  The present study investigates the effect of cyclohexylmethyldithiocarbamates sodium salt (a synthetic compound) and vitamin E against diclofenac-induced blood and testes of experimental Wistar male albino rats. The study consists of six groups of six rats each. Group I (control) received corn oil (3 ml/kg b.w), Group II received diclofenac (100 mg/kg b.w), Group III rats were treated with diclofenac and cyclohexylmethyldithiocarbamates sodium salt (30 mg/kg b.w), Group IV was administered diclofenac and Vitamin E (30 mg/kg b.w), Group V was given cyclohexylmethyldithiocarbamates sodium salt (30 mg/kg b.w) only and Group VI received vitamin E only. The results showed a significant (p<0.05) decrease in the daily sperm production in the diclofenac only treated rats, diclofenac with Na (HxMedtc), diclofenac with vitamin E treated rats and Na (HxMedtc) treated rats but no significant (.. View More»
  DOI: 10.4172/2167-0501.1000155

  Abstract PDF

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