Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Adelheid Elbe-Bürger
Department of Dermatology, DIAID, Währinger Gürtel 18-20, Room Nr. 4P904, 1090 Vienna, Europe
Austria
Research Article
Most T Cells in Human Neonatal Skin are Not Naive
Author(s): Johnnie Akgün, Marion Prior and Adelheid Elbe-BürgerJohnnie Akgün, Marion Prior and Adelheid Elbe-Bürger
T cells present in human skin are involved in cutaneous immune surveillance but can also contribute actively to inflammatory skin diseases. In healthy human adult skin, T cells mainly belong to the CD45RO+ memory population. In contrast, human fetal skin contains predominantly CD45RA+ naive T cells. In this study, we elucidated the T cell composition in human skin samples after birth to unravel whether the change of the microenvironment influences the cutaneous T cell repertoire. Double-immunofluorescence staining on skin cryostat sections revealed that the majority of CD3+ T cells in human neonatal epidermis as well as dermis displayed a memory phenotype and that their numbers progressively increased with age. While naive T cells were observed in neonatal dermis, these cells were not present in neonatal epidermis. Some rare naive T cells appeared in infant epidermis. Taken toge.. View More»
DOI:
10.4172/2155-9554.S2-004