Journal of Alcoholism & Drug Dependence
Open Access
ISSN: 2329-6488
ISSN: 2329-6488
Adewale Adetutu
Nigeria
Research Article
Hematological and Biochemical Changes in Blood, Liver and Kidney Tissues under the Effect of Tramadol Treatment
Author(s): Abiodun Olusoji Owoade, Adewale Adetutu and Olubukola Sinbad OlorunnisolaAbiodun Olusoji Owoade, Adewale Adetutu and Olubukola Sinbad Olorunnisola
This study aimed to investigate the effects of tramadol administration on some haematological and biochemical indices in rats. Tramadol was administered orally to rats for 28 days at a dose of 10 mg/kg body weight/day, 50 mg/kg body weight/day and 100 mg/kg body weight/day. Twenty-four hours after the last tramadol, blood, liver and kidney were removed from the animals after an overnight fast and analysed for their haematological and biochemical parameters. Results obtained revealed that tramadol administration significantly reduced the levels of white blood cells (WBC), red blood cell (RBC), haemoglobin and platelet count (PLT) while its resulted in non-significant changes in other haematological parameters examined when compared with control rats. Tramadol intake significantly increased plasma levels of alkaline phosphatase (ALP), aspartate aminotransferase (AST), creatinine and ure.. View More»
DOI:
10.35248/2329-6488.19.7.326