Rheumatology: Current Research
Open Access

Adrian Crawley

Publications

• Research Article
  Responsiveness of Bold MRI to Short-Term Temperature Changes in Rabbit Knees with Inflammatory Arthritis
  Author(s): Cristina Nasui, George Nathanael, Elka Miller, Jaques Belik, Adrian Crawley, Ruth Weiss, Garry Detzler, Anguo Zhong, Rahim Moineddin and Andrea S DoriaCristina Nasui, George Nathanael, Elka Miller, Jaques Belik, Adrian Crawley, Ruth Weiss, Garry Detzler, Anguo Zhong, Rahim Moineddin and Andrea S Doria
  
  Objectives: Tissue signal change caused by temperature-dependent alterations in the affinity of oxygen for hemoglobin contributes to BOLD contrast. Our goals were to test whether BOLD MRI contrast changes with short-term variations in joint temperature (internal responsiveness) and to determine whether an association exists between BOLD MRI and intraarticular pO2 and blood flow [reference standards] upon joint temperature changes (external responsiveness). Methods: Seven juvenile rabbits had the carrageenin (antigen)-injected knee imaged, 10 had the contralateral knee imaged and 11 had one of non-injection knees imaged. Assigned knees underwent experimentally forced increased (37°-42°C) or decreased (37°- 30°C) local temperature for 15-minute periods using heating/cooling pads and were subsequently imaged. Intra-articular p.. View More»
  DOI: 10.4172/2161-1149.S2-003

  Abstract PDF

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