Journal of Hematology & Thromboembolic Diseases
Open Access

Adrien Joseph

Publications

• Case Report
  Seasonal Flu as a Triggering Factor for Acquired Thrombotic Thrombocytopenic Purpura
  Author(s): Joseph A, Fangio P, Barbier C, Hayon J, Loubières Y, et al. Joseph A, Fangio P, Barbier C, Hayon J, Loubières Y, et al.
  
  A 47 years old woman was admitted to our intensive care unit for acute asthma. An infection by influenza virus A was diagnosed and the patient presented during her hospitalization signs of thrombotic microangiopathy. Biologic analysis showed low A Desintegrin and Metalloproteinase with ThromboSpondin 1 - motifs - member 13 (ADAMTS13) activity and positive anti-A Desintegrin And Metalloproteinase with ThromboSpondin 1 - motifs - member 13 antibodies. Diagnosis of Acquired Thrombotic Thrombocytopenic Purpura was considered and a specific treatment was started with plasma exchange and intravenous administration of rituximab for relapse. Acquired Thrombotic Thrombocytopenic Purpura is considered an auto-immune disease. As such, it can be triggered by bacterial or viral infection. Many triggering factors have been described. Testing for influenza virus should be considered in epidemic situati.. View More»
  DOI: 10.4172/2329-8790.1000243

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