Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Adubl-Wahab Razooqi Hamad
Zarka University College,
13115
Jordan
Research Article
Role of Oxidative Stress and Chlamydia trachomatis in Infertile Women with Anti-Zona Pellucida Autoantibodies
Author(s): Adubl-Wahab Razooqi Hamad, Hala I Al-Daghistani, Mayas Khadra and Esraa Abdullatif AlethawiAdubl-Wahab Razooqi Hamad, Hala I Al-Daghistani, Mayas Khadra and Esraa Abdullatif Alethawi
Female infertility could be attributed to various factors including; sperm isoantobody, zona pellucid antibody, ovarian antibody, Chlamydia trachomatis infection and imbalance between oxygen radical and antioxygen radical. These factors might impair infertility by different mechanisms.
A retrospective case-control study was performed on 105 infertile female including 75 (71.4%) with primary infertility and 30 (28.6%) with secondary infertility. Thirty healthy women were used as a control. Antisperm antibody (ASA), antizona pelucida antibody (AZP-Ab) and antiovarian antibody (AOA) were detected in the serum and cervical secretion using Enzyme labeled and Biotin labeled antibody. PCR technique was applied to detect the presence of Chlamydia trachomatis in the cervical secretion using the following primers: KL1-F and KL2-R, whereas IgG specific antibody was ex.. View More»
DOI:
10.4172/2167-0501.1000249