Clinical & Experimental Cardiology
Open Access

Ahmad Almudhafer

Publications

• Research Article
  Effect of Vildagliptin on Atherosclerosis Progression in High Cholesterol –Fed Male Rabbits
  Author(s): Najah R Hadi, Hussain Abdulkadhim, Ahmad Almudhafer and Sahar A MajeedNajah R Hadi, Hussain Abdulkadhim, Ahmad Almudhafer and Sahar A Majeed
  
  Background: Atherosclerosis is a progressive disease of large and medium-sized arteries characterized by the accumulation of lipids and fibrous elements in the large arteries. Aim of the study: This study was undertaken to assess the effect of vildagliptin on the progression of atherosclerosis via interfering with inflammatory and oxidative pathways. Materials and Methods: 18 local domestic male rabbits were included in this study. The animals were randomly divided into three groups (6 rabbits for each group): Group I rabbits fed normal chow (oxiod) diet for 12 weeks. Group II rabbits fed 1% cholesterol enriched diet for 12 weeks. Group III rabbits fed with cholesterol enriched diet for 6 weeks, and then continued on cholesterol-enriched diet and treated with vildaglipin 50 mg/kg/day orally for the next 6 weeks. Blood samples were collected at.. View More»
  DOI: 10.4172/2155-9880.1000249

  Abstract PDF

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