Clinical & Experimental Cardiology
Open Access

Ahmad Almudhafer

Publications

• Research Article
  Monteleucast and Zileuton Retard the Progression of Atherosclerosis via Down Regulation of the Inflammatory and Oxidative Pathways
  Author(s): Najah R Hadi, Bassim I Mohammad, Ahmad Almudhafer, Naser Yousif and Ahmed M SultanNajah R Hadi, Bassim I Mohammad, Ahmad Almudhafer, Naser Yousif and Ahmed M Sultan
  
  Background: Atherosclerosis and its thrombotic complications are responsible for remarkably high numbers of deaths. Leukotrines are involved in different stages of atherosclerosis. Therefore this study was undertaken to evaluate the effect of montelukast and zileuton on the progression of atherosclerosis. Materials and methods: Thirty-five male rabbits were used in this study. These animals randomized into 5 groups (7 rabbits each). Rabbits in first group were maintained on normal rabbit chow diet and used as normal diet control group (NC). While the rabbits in other four groups were fed on atherogenic diet (2% cholesterol) for 8 weeks. The second group, Atherogenic Control Group (AC) rabbits received atherogenic diet alone. Third group, Positive Control Group (PC) rabbits received atherogenic diet and ethanol as vehicle. Forth group, Monteluk.. View More»
  DOI: 10.4172/2155-9880.1000250

  Abstract PDF

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