Journal of Applied Pharmacy
Open Access

Ahmad Salahuddin

Publications

• Research Article
  Effects of Grape Seed Proanthocyanidin Extract in Attenuating Diabetic Complications in Streptozotocin-Induced Diabetic Rats
  Author(s): Ahmad Salahuddin and Mohamed Katary Ahmad Salahuddin and Mohamed Katary
  
  Oxidative stress is a major cause for development and progression of diabetic mediated peripheral and central complications. The aim of this work is to evaluate the role of Grape Seed Proanthocyanidin (GSPE) extract in attenuating diabetic complications. Forty-five adult male Wistar rats were divided into three groups. Control, non-treated diabetic and diabetic rats treated with GSPE. Diabetes was induced by intraperitoneal injection of streptozotocin. After eight weeks; urine, blood and brain, heart, kidneys, liver tissue homogenate parameters were evaluated. The results showed a reduction in both renal and hepatic function in non-treated group as well as an elevated serum inflammatory markers (TNF-α, hs-CRP and IL-6). In addition, there were an elevation in both serum and different tissue homogenate oxidative stress parameters (SOD, GPx, Catalase and MDA). Treatments with GSPE.. View More»
  DOI: 10.21065/1920-4159.1000239

  Abstract PDF

Relevant Topics