Biochemistry & Pharmacology: Open Access
Open Access

Akakuru OC

Publications

• Research Article
  The Chemistry of Chitin and Chitosan Justifying their Nanomedical Utilities
  Author(s): Akakuru OU, Louis H, Amos PI, Akakuru OC, Nosike EI and Ogulewe EF Akakuru OU, Louis H, Amos PI, Akakuru OC, Nosike EI and Ogulewe EF
  
  Chitin and chitosan are among the most commonly used natural polymers in nanomedicine because they display very attractive characteristics for drug delivery and have proven very effective when formulated in nanoparticle forms. Properties such as the cationic character and the solubility of chitosan in aqueous medium have been reported as determinants of the success of this polysaccharide. However, its most attractive property relies on its ability to adhere to mucosal surfaces, leading to prolonged residence time at drug absorption sites and enabling higher drug permeation. This is because chitin and chitosan are able to interact with anionic agents and form water-soluble barriers which participate in drug release. The wide nanomedical applications of chitin and chitosan are due not only to their excellent biocompatibility, biodegradability, non-toxicity, ordourless nature and economi.. View More»
  DOI: 10.4172/2167-0501.1000241

  Abstract PDF

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