Journal of Proteomics & Bioinformatics
Open Access

Alan J Tackett

Publications

• Research Article
  A Quantitative Proteomic Analysis of Urine from Gamma-Irradiated Non- Human Primates
  Author(s): Stephanie D Byrum, Marie S Burdine, Lisa Orr, Linley Moreland, Samuel G Mackintosh, Simon Authier, Mylene Pouliot, Martin Hauer- Jensen and Alan J TackettStephanie D Byrum, Marie S Burdine, Lisa Orr, Linley Moreland, Samuel G Mackintosh, Simon Authier, Mylene Pouliot, Martin Hauer- Jensen and Alan J Tackett
  
  The molecular effects of total body gamma-irradiation exposure are of critical importance as large populations of people could be exposed either by terrorists, nuclear blast, or medical therapy. In this study, we aimed to identify changes in the urine proteome using a non-human primate model system, Rhesus macaque, in order to characterize effects of acute radiation syndrome following whole body irradiation (Co-60) at 6.7 Gy and 7.4 Gy with a twelve day observation period. The urine proteome is potentially a valuable and non-invasive diagnostic for radiation exposure. Using high-resolution mass spectrometry, we identified 2346 proteins in the urine proteome. We show proteins involved in disease, cell adhesion, and metabolic pathway were significantly changed upon exposure to differing levels and durations of radiation exposure. Cell damage increased at a faster rate at 7.4 Gy compared.. View More»
  DOI: 10.4172/jpb.S10-005

  Abstract PDF

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