Journal of Clinical and Cellular Immunology
Open Access

Alan L. Epstein

Publications

• Research Article
  Exploring the Therapeutic Efficacy of Glioma Vaccines Based on Allo- and Syngeneic Antigens and Distinct Immunological Costimulation Activators
  Author(s): Apostolos Stathopoulos, Chrystel Pretto, Laurent Devillers, Denis Pierre, Florence M. Hofman, Alan L. Epstein, Hooman Farghadani, Carol A. Kruse, Martin R. Jadus, Thomas C. Chen and Virgil E.J.C. Sc Apostolos Stathopoulos, Chrystel Pretto, Laurent Devillers, Denis Pierre, Florence M. Hofman, Alan L. Epstein, Hooman Farghadani, Carol A. Kruse, Martin R. Jadus, Thomas C. Chen and Virgil E.J.C. Sc
  
  The efficacy of a various immunotherapeutic immunisation strategies for malignant glioma brain cancer was evaluated in the syngeneic CNS-1 Lewis rat glioma model. A prototype glioma cancer vaccine, which was composed of multivalent antigens derived from allogeneic and syngeneic cells and lysates, formed the prototype preparation of antigens. These antigens reflect the autologous antigens derived from the patient’s surgically removed tumor tissue, as well as allogeneic antigens form glioma tumor tissue surgically removed from donor patients. This antigen mixture provides a broad spectrum of tumor associated antigens (TAA) and helps to prevent escape of tumor immune surveillance when given as a vaccine. This antigen preparation was administered in a therapeutic setting with distinct single or multiple co-stimulation-favouring immunostimulants and evaluated for inhibition of tumor .. View More»
  DOI: 10.4172/2155-9899.S5-004

  Abstract PDF

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