Journal of Drug Metabolism & Toxicology
Open Access

Al-Bawab AQ

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• Commentary
  The Frequency of UGT2B7*2 (802C>T) Allele among Healthy Unrelated Jordanian Volunteers
  Author(s): Jarrar YB, Kherfan F, Obaid A, Hamadneh L and Al-Bawab AQJarrar YB, Kherfan F, Obaid A, Hamadneh L and Al-Bawab AQ
  
  The UDP-Glucuronesyl Transferase (UGT) 2B7*2 802C>T is the most common functional genetic variant on UGT2B7 gene with reported influence on drug response. Objective: To determine the frequency of UGT2B7*2 (802C>T) genetic variant among Jordanian population. Methods: The DNA samples from 90 healthy Jordanian volunteers were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism assays (PCR-RFLP) to determine the UGT2B7*2 allele. Results: The frequency (95% confidence interval) of UGT2B7*2 802C allele was 0.59 (0.52 to 0.66) and for UGT2B7*2 802T was 0.41 (0.34 to 0.48), which was similar to the Caucasian but different than African ethnic populations. The UGT2B7 genotype frequency among Jordanians was 0.31 (0.22 to 0.4) for wild, 0.57(0.47 to 0.67) for heterozygote and 0.12 (0.06 to 0.18) for homozygote UGT2B7*2 genotype. Conclusion: This study .. View More»
  DOI: 10.4172/2157-7609.1000218

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