Medicinal & Aromatic Plants
Open Access

Alberto Maria Cattaneo

Publications

• Research Article
  Perilla Derived Compounds Mediate Human TRPA1 Channel Activity
  Author(s): Alberto Maria Cattaneo, Yuriy V Bobkov, Elizabeth A Corey, Gigliola Borgonovo and Angela Bassoli Alberto Maria Cattaneo, Yuriy V Bobkov, Elizabeth A Corey, Gigliola Borgonovo and Angela Bassoli
  
  Compounds from food plants affecting the somatosensory system, like Perilla frutescens (L.), are well known for their flavoring, pharmacological and medical properties. Yet the exact mechanisms underlying their activity are still poorly understood. Transient Receptor Potential (TRP) channels involved in chemestetic sensations likely represent some of the primary targets for these compounds. Using a heterologous expression system and calcium imaging we show that a number of Perilla derived compounds (S-(-)-1,8-p-menthadiene-7-al (perillaldehyde, PA); 3-(4-methyl- 1-oxopentyl)furan (perillaketone, PK); 1,2,4-trimethoxy-5-[(E)-prop-1-enyl]benzene (α-asarone, ASA)) and synthetic compounds derivative from Perilla (3-(4-methoxy-phenyl)-1-furan-2-yl-propenone (PK-16) and 3-(4-chloro-phenyl)- 1-furan-2-yl-propenone (PK-18)) are capable of activating the human TRP Ankyrin family channel .. View More»
  DOI: 10.4172/2167-0412.1000283

  Abstract PDF

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