Rheumatology: Current Research
Open Access

Alex Magno Coelho Horimoto

Publications

• Research Article
  Anti-Collagen Type V Antibody in Systemic Sclerosis: A Possible Useful Tool to Asses Disease Activity
  Author(s): Alex Magno Coelho Horimoto, Natalino Hajime Yoshinari, Elenice Mantovani and Izaias Pereira da Costa Alex Magno Coelho Horimoto, Natalino Hajime Yoshinari, Elenice Mantovani and Izaias Pereira da Costa
  
  Introduction: Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury, autoimmunity and tissue fibrosis. Usually collagen type V (V Col) is found hidden between the heterotypical fibers. It was discovered in the rheumatology department at the University of São Paulo (FMUSP) that deposition of this collagen occurs, however with anomalous morphology in SSc patient’s tissue, suggesting that V Col is an important molecule in fibrosis and autoimmunity process. The V Col molecule, which has atypical morphology aspect, exposed after a nonspecific inflammatory damage could result in formation of immune complexes (V Col - anti-V Col), whose deposition on the vascular endothelium, would cause a vascular damage, allowing the influx of cells of innate immunity into the extracellular matrix, resulting in an enzymatic degradation of the heter.. View More»
  DOI: 10.4172/2161-1149.1000188

  Abstract PDF

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