Fungal Genomics & Biology
Open Access
ISSN: 2165-8056
ISSN: 2165-8056
Ali A
India
Research Article
Acetylcholine Induces Yeast to Hyphal Form Transition in Candida albicans
Author(s): Awad Ali, Sankunny Mohan KaruppayilAwad Ali, Sankunny Mohan Karuppayil
Background: In Candida albicans, yeast to hyphal form transition can be induced by serum, proline, glucose, and N-acetylglucosamine. Acetylcholine is a neuromodulator which can stimulate both muscarinic and nicotinic acetylcholine receptors in humans. In this study, we are reporting that acetylcholine can induce yeast to hyphal form transition in C. albicans. The adenylyl cyclase inhibitor, MDL 12, 330A inhibited this transition indicating the role of cAMP. Muscarinic receptors in C. albicans did not report yet. We have reported that C. albicans Rrp9 exhibits identity and similarity with the human muscarinic receptor M1. In humans, activation of muscarinic M1 receptor can produce cAMP through inositol phosphate pathway. The inositol phosphate pathway in C. albicans is already known. We have carried out the local and global alignment sequences between the proteins of humans and C. albi.. View More»
DOI:
10.4172/2165-8056.1000154