Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Ali Sultan Al-Refai
Iraq
Research Article
Effect of Chamomile Extract on the Tongue of Chemotherapy Treated Albino Rats (Histopathological and Immunohistochemical Study)
Author(s): Ali Sultan Al-Refai, Othman A. Omar and Ameera Kamal KhalilAli Sultan Al-Refai, Othman A. Omar and Ameera Kamal Khalil
Background and objectives: 5-Fluorouracil (5-FU) is a commonly used drug for the treatment of malignant cancers. The control of oral mucositis result from 5-FU use is becoming increasingly more important, and effective intervention is considered a high priority in cancer patient care. The aim of this study was to investigate the effect of chamomile extract on the pathogenesis of 5-FU induced tongue mucositis in Albino rat.Materials and methods: In current study forty female Albino rats, weighing 220-280 g were used. For the induction of mucositis, 60 mg/kg of 5-FU was administered intraperitoneally to each animal in the study group on day 0, and 40 mg/kg was administered on day 2. The control animals were intraperitoneally injected by normal saline in the same manner and dose like 5-FU on day 0 and 2. Then the rats in each group were randomly di.. View More»
DOI:
10.4172/2155-9899.1000251