Reproductive System & Sexual Disorders: Current Research
Open Access

Aline Amaro dos Santos

Publications

• Research Article
  Correlation between Chromosomal Variants and Male Infertility in a Population of Brazilian Infertile Men
  Author(s): Denise Maria Christofolini, Fernanda Abani Mafra, Rubens Pedrenho Neto, Raphael Augusto Saab de Almeida Barros, Aline Amaro dos Santos, Carla Peluso, Marcello Machado Gava, Milton Ghirelli-Filho, Bianca Bianco and Caio Parente Barbosa Denise Maria Christofolini, Fernanda Abani Mafra, Rubens Pedrenho Neto, Raphael Augusto Saab de Almeida Barros, Aline Amaro dos Santos, Carla Peluso, Marcello Machado Gava, Milton Ghirelli-Filho, Bianca Bianco and Caio Parente Barbosa
  
  Heterochromatin polymorphism is considered a variant of a normal karyotype but is more frequent in infertile men. The aim of this study was to evaluate the correlation between heterochromatic variants and male infertility and to discuss the possible mechanisms of how heterochromatic polymorphism might affect spermatogenesis. Methods: Cytogenetic analysis was undertaken in a group of 392 infertile men from the Andrology Outpatient Clinic of the Human Reproduction Service of the ABC School of Medicine. Additionally, C-banding was performed in men with heterochromatin polymorphism, and NOR-banding in men with satellites variations. Results: 47 patients of the sample showed chromosomal variants (12% of the sample). Considering these men, 8 presented idiopathic infertility, where 19 presented severe oligozoospermia, 18 had non-obstructive .. View More»
  DOI: 10.4172/2161-038X.1000105

  Abstract PDF

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