Journal of Glycobiology
Open Access
ISSN: 2168-958X
+44 1478 350008
ISSN: 2168-958X
+44 1478 350008
Alok Raghav
Rajiv Gandhi Centre for Diabetes and Endocrinology, J.N Medical College,
Aligarh-202002, UP
India
Review Article
Current Insights in Mammalian Glycosylation: Implication of Glycoproteomics as Next-Generation Biomarkers in Diabetes Mellitus
Author(s): Alok Raghav, Jamal Ahmad, Zeeshan Ahmad Khan, Brijesh Kumar Mishra and Rai Pawankumar AnirudhAlok Raghav, Jamal Ahmad, Zeeshan Ahmad Khan, Brijesh Kumar Mishra and Rai Pawankumar Anirudh
Glycosylation, an enzyme-directed, site-specific process is one of the major co-translational and post-translational modifications in proteins. So formed product, glycoproteins, mediate multiple functions of signal transductions, cell association, and inter and intra cell signalling. Glycoproteomics exploits all these biological functions and serves as the next generation diagnostic marker for analyzing proteins that are associated with micro- and macro-vascular complication of diabetes mellitus. This tool can unreveal the secrets of the patterned expression of glycoproteins in healthy and patients with diabetes with secondary complications. The expression profile of several O-linked and Nlinked mammalian glycoproteins delivers the knowledge and helps to create a database for expression in diabetes mellitus, for proposing a mechanistic approach to understanding the cellular pathway se.. View More»
DOI:
10.4172/2168-958X.1000125