Journal of Leukemia
Open Access

Amal Zaghloul

Publications

• Research Article
  Membranous Expression of pan CD66, CD66a, CD66b, and CD66c and their Clinical Impact in Acute Leukemia: Cross Sectional Longitudinal Cohort Study in Saudi Arabia
  Author(s): Manar M. Ismail1,Amal Zaghloul, Abdulateef Nahla AB and Morsi Heba K Manar M. Ismail1,Amal Zaghloul, Abdulateef Nahla AB and Morsi Heba K
  
  CD66 and its isoforms modulate several physiologic processes and have a role in aggressiveness of malignancies. We aimed at investigating pan CD66, CD66 a, b, and c expression and their clinical implication in acute leukemia. This study included 85 cases, 50 AML, 33 ALL and 2 mixed lineage leukemia from King Abdullah Medical City, Saudi Arabia. Pan CD66, CD66a, CD66b and CD66c were detected by flow cytometry at diagnosis and pan CD66 was reanalyzed at day28. Pan CD66 and CD66c expression rate was 51.8% in B-ALL and significantly correlated with BCR/ABL gene, P-value 0.037. CD66a was detected in 11.1% and significantly associated with shorter overall survival (OS), P-value 0.045. In AML, the expression rates were 40%, 28% and 32% for pan CD66, CD66b and CD66c respectively. CD66b was significantly correlated with favorable cytogenetic and prolonged OS, P-value 0.001 and 0.025 respective.. View More»
  DOI: 10.4172/2329-6917.1000230

  Abstract PDF

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