Advanced Techniques in Biology & Medicine
Open Access
ISSN: 2379-1764
ISSN: 2379-1764
Special Issue Article
Assessment of the Genotoxic and Antioxidant Activities of Several Vegetables, Spices and
Herbs in Combination with Cyclophosphamide and 4-Nitroquinoline n-Oxide in Drosophila Melanogaster
Author(s): América Nixtin Castañeda Sortibrán, María Guadalupe Ordaz Téllez and Rosario Rodríguez Arnaiz
América Nixtin Castañeda Sortibrán, María Guadalupe Ordaz Téllez and Rosario Rodríguez Arnaiz
It has been demonstrated that the juices from several vegetables, spices and herbs protect against certain carcinogens. The antioxidant capacity of several vegetables has been documented. The aims of the present study were to evaluate the genotoxicity of celery, coriander, epazote, parsley and watercress using the Somatic Mutation and Recombination Test (SMART) on the wings of Drosophila melanogaster using Standard (ST) and High Bioactivation (HB) crosses with regular and high levels of metabolizing cytochrome P450 enzymes, respectively. The protective effects of the extracts against 4-Nitroquinoline n-Oxide (4NQO) 4NQO, an oxidant compound, and Cyclophosphamide (CP), an alkylating agent, were evaluated. Both promutagens were employed alone as positive controls and in combination with the extracts. The majority of the extracts were non-genotoxic, although several positive results were.. View More»
DOI:
10.4172/2379-1764.S1-002