Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Amelie Witte
Germany
Review Article
Emerging Roles of ADAP, SKAP55, and SKAP-HOM for Integrin and NF-κB Signaling in T cells
Author(s): Amelie Witte, Janine Degen, Kathleen Baumgart, Natalie Waldt, Benno Kuropka, Christian Freund, Burkhart Schraven and Stefanie KlicheAmelie Witte, Janine Degen, Kathleen Baumgart, Natalie Waldt, Benno Kuropka, Christian Freund, Burkhart Schraven and Stefanie Kliche
Adapter proteins are scaffolding proteins that lack enzymatic or transcriptional activity. They play a crucial role in the organization of signalosomes, which are molecular complexes involved in signal transduction. Here, we review some of the recent findings regarding the three cytosolic adapter proteins ADAP, SKAP55, and SKAP-HOM with respect to their role in T-cell adhesion, migration and proliferation... View More»
DOI:
10.4172/2155-9899.S12-002