Journal of Thermodynamics & Catalysis
Open Access

Amine Mehablia

Publications

• Research Article
  Oxidation of Tricyclic Antidepressant Agent, Amitriptyline, by Permanganate in Sulphuric Acid Medium: Kinetic and Mechanistic Approach
  Author(s): Shekappa D. Lamani and Sharanappa T. NandibewoorShekappa D. Lamani and Sharanappa T. Nandibewoor
  
  The kinetics of oxidation of amitriptyline by potassium permanganate in aqueous sulphuric acid medium at 298K and at a constant ionic strength of 0.20 mol dm-3 has been investigated spectrophotometrically. The reaction exhibits 5:4 stoichiometry (5 Amitriptyline:4 KMnO4). The reaction was first order with respect to manganese(VII) concentration. The order with respect to amitriptyline was found to be less than unity (0.80). Increase in acid concentration increased the rate. The order with respect to acid concentration was also less than unity (0.40). The effect of added products, ionic strength and dielectric constant have been studied on the rate of reaction. The oxidation products were identified by using 2,4 DNP derivative, IR, GCMS spectral studies. A suitable mechanism was proposed on the basis of experimental results. The reaction constants involved .. View More»
  DOI: 10.4172/2157-7544.1000110

  Abstract PDF

Relevant Topics