Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-77-2385-9429
ISSN: 2157-7609
+44-77-2385-9429
Amro A Abd-Elgayd
Egypt
Research Article
Effect of Nandrolone Decanoate (Anabolic Steroid) on the Liver and Kidney of Male Albino Rats and the Role of Antioxidant (Antox-Silymarin) as Adjuvant Therapy
Author(s): Marwa A Mwaheb, Amal RS Mohammed, Ghada M Al-Galad, Amro A Abd-Elgayd and Hala M Al-hambolyMarwa A Mwaheb, Amal RS Mohammed, Ghada M Al-Galad, Amro A Abd-Elgayd and Hala M Al-hamboly
Background and objective: The present study is determining the effect of Nandrolone Decanoate (ND) administration on the liver and kidney of white male albino rats. In addition, study the possible protective effect of administration of Antox and Silymarin on ND. Methods: The sample consisted of 110 male albino rats that divided into eleven groups treated by Nandrolone Decanoate at a dose of 7.93 mg/kg and 11.9 mg/kg then treated by Silymarin or Antox or both for 8 weeks. The variations in the body weight and weight of liver & kidney organs of rats are determined in all different groups in addition to the variation in liver enzymes (ALT-AST), bilirubin level, kidney function tests: Creatinine and blood urea level among different study groups are measured. The present study represents the hepatic and renal histological changes observed among the different groups. Results: The high.. View More»
DOI:
10.4172/2157-7609.1000224