Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Amro Abd Al Fattah Amara
Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technological Applications, Alexandria, Universities and Research Center District, New Borg EL-Arab,
Egypt
Research Article
The Need for Early Detection of the Prototype Mutants: Sickle Cell Anemia as a Case Study
Author(s): Amro Abd Al Fattah AmaraAmro Abd Al Fattah Amara
It is basic knowledge that three of the DNA nucleotides are code for one amino acid. That cause some sort for protection, while in many cases one nucleotide change did not lead to a new amino acid (silent mutant). However, we should not neglect such silent mutant particularly if it has happened in a sensitive gene such as β-globin. Such silent mutant is the base for a complete mutant, which might cause severe disease. Because protein is the macromolecules, which responsible for most of the cell functions, most studies are done so far on the protein level including, comparing protein sequences. Genetic diseases could be happened due to one nucleotide change, which could be responsible about causing dramatic illness such as the Sickle cell anemia. However, sometimes there is a need for two or even three nucleotide changes to mutate a single amino acid. Such change(s) might take lon.. View More»
DOI:
10.4172/jpb.S8-006