ISSN: 2155-9880
+44 1300 500008
Ana Helena Willrich Rasera
Brazil
Research Article
Bone Marrow Mononuclear Stem Cell Transplant in Acute and Chronic Arterial Insufficiency in Rabbits
Author(s): Elizana Rasera, Julio Cesar Francisco, Rossana Simeoni, Gustavo Bono, Ana Helena Willrich Rasera, Cristina Pellegrino Baena, Katherine Athayde Teixeira de Carvalho, Ricardo Cunha, Rafael Michel de Macedo, Vivian Ferreira do Amaral, Marcia Olandoski, Jose Rocha Faria-Neto and Luiz Cesar Guarita-SouzaElizana Rasera, Julio Cesar Francisco, Rossana Simeoni, Gustavo Bono, Ana Helena Willrich Rasera, Cristina Pellegrino Baena, Katherine Athayde Teixeira de Carvalho, Ricardo Cunha, Rafael Michel de Macedo, Vivian Ferreira do Amaral, Marcia Olandoski, Jose Rocha Faria-Neto and Luiz Cesar Guarita-Souza
Introduction: There is a high incidence of Peripheral Obstructive Arterial Disease (POAD) in patients with atherosclerosis. In more complex cases for which surgical revascularization is not possible, the only option involves clinical treatment that in the majority of cases evolves to amputation of the limb. Transplant of mononuclear stem cells from bone marrow has presented favorable results in chronic obstructions.
Objective: To perform a functional analysis of the effect of bone marrow mononuclear stem cell transplant on acute arterial occlusion immediately and 48 hours after occlusion, comparing between groups and with controls.
Materials and methods: Twenty New Zealand rabbits were anesthetized with ketamine and xylazine (50 mg/ kg) and underwent occlusion of the right iliac artery. Those animals that presented abs.. View More»
DOI:
10.4172/2155-9880.S11-005