Andrology-Open Access
Open Access

Ana Rabaça

Publications

• Research Article
  Assessing Male Reproductive Toxicity during Drug Development
  Author(s): Mario Sousa, Carolina Ferreira, Ana Rabaca and Rosália Sa Mario Sousa, Carolina Ferreira, Ana Rabaca and Rosália Sa
  
  Pharmaceutical development is a crucial research field that attends to the population healthcare needs, comprising several preclinical and clinical steps before the approval of a new compound. Interestingly, the lack of efficacy and toxicity are known major failure causes during pharmaceutical drug development. Toxicity screening is therefore a mandatory procedure during pharmaceutical development. Renal and hepatic toxicity are the most common toxicity matters encountered during the development of new compounds. Nonetheless, the male reproductive system may also be a target for drug toxicity. However, developmental and reproductive toxicology testing is rarely performed both in pre-clinical and clinical trial phases. As a result, there are several risks for human fertility brought on by putative toxic chemical compounds. As there is a low incidence of reproductive and testicular toxi.. View More»
  DOI: 10.4172/2167-0250.1000185

  Abstract PDF

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