Journal of Hematology & Thromboembolic Diseases
Open Access

Anas Alsara

Publications

• Review Article
  Advances in the Treatment of Hairy Cell Leukemia
  Author(s): Anas Alsara, Akshay Amaraneni, Sreenivasa R. ChandanaAnas Alsara, Akshay Amaraneni, Sreenivasa R. Chandana
  
  Hairy cell leukemia is relatively rare, chronic low grade B-cell leukemia. It is characterized morphologically by cells with abundant cytoplasm and “hair”-like projections that can be found within the peripheral blood, bone marrow or splenic pulp. Like many cancers, the treatment for hairy cell leukemia has evolved considerably in the last several years. In the mid 1980s, the acceptable treatment was splenectomy and later interferon therapy, which is quickly falling out of favor with the advent and acceptance of purine analog therapy. In addition, we now have several biologic agents that are coming into favor based on their improved success and favorable toxicity. In addition, several studies are currently looking into the efficacy of purine analogs in conjunction with biologic agents. Rituximab, alemtuzumab and recombinant immunotoxins are being studied with limited succe.. View More»
  DOI: 10.4172/2329-8790.1000210

  Abstract PDF

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