Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Angelika Mennecke
Germany
Research Article
Voxel Based Analysis of Diffusion Indices in Patients with Primary Open-Angle Glaucoma Using Tract-Based Spatial Statistics
Author(s): Manuel A. Schmidt, Sultan Haider, Angelika Mennecke, Richard Johnson, Joachim Hornegger, Georg Michelson, Arnd Doerfler1 and Tobias EngelhornManuel A. Schmidt, Sultan Haider, Angelika Mennecke, Richard Johnson, Joachim Hornegger, Georg Michelson, Arnd Doerfler1 and Tobias Engelhorn
Background and purpose: Diffusion tensor imaging can provide information about microstructural changes of the visual pathway in glaucoma patients. Tract-based spatial statistics (TBSS) has been established for analysis of fractional anisotropy (FA) and has successfully been used for analysis of DTI data of glaucoma patients. However there are certain DTI indices such as mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD) and mode of anisotropy (MO), which can also be analyzed using TBSS. Hence, we tested whether TBSS is useful for analysis of non-FA data in glaucoma patients and for identification of microstructural changes in patients with primary openangle glaucoma characterized by these non-FA DTI indices. Material and methods: Our study comprised 46 patients with primary open-angle glaucoma (POAG) and a healthy, age-match.. View More»
DOI:
10.4172/2155-9570.1000415