Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Angeliki Kakavouti-Doudou
Greece
Research Article
The Efficacy of Voriconazole Eye Drops Reconstituted in Sterile Water for Injection
Author(s): Timoleon-Achilleas Vyzantiadis, Asterios Diafas, Anthi-Marina Markantonatou, Evaggelia Zachrou, Angeliki Kakavouti-Doudou, Diamantis Almaliotis and Vasileios KarampatakisTimoleon-Achilleas Vyzantiadis, Asterios Diafas, Anthi-Marina Markantonatou, Evaggelia Zachrou, Angeliki Kakavouti-Doudou, Diamantis Almaliotis and Vasileios Karampatakis
Purpose: To investigate the efficacy of voriconazole 1% eye drops reconstituted in sterile water for injection and stored in the fridge or room conditions and correlate the results to bibliographic data. Methods: Voriconazole powder was reconstituted with water for injection, in order to prepare a 1% solution. The solution was separated in sterile vials stored in the fridge or in the cupboard. Malt extract agar solutions were prepared with the addition of this voriconazole solution to achieve concentrations of 1 μg/ml, 2 μg/ml and 4 μg/ml and the same procedure was repeated after one and after two weeks. Petri plates were inoculated with standardized solutions of Candida albicans, Aspergillus fumigatus, Alternaria alternata, Fusarium solani and Fusarium oxysporum. The fungal growth was compared to the control plates, which contained only malt extract agar without vorico.. View More»
DOI:
10.4172/2155-9570.1000481