Journal of Clinical Chemistry and Laboratory Medicine
Open Access

Angeline Yasodhara

Publications

• Research Article
  Bisalbuminemia: Lack of Association with Monoclonal Gammopathy and Value-Justification for Reporting in Serum Protein Electrophoresis
  Author(s): Pak Cheung Chan, Angeline Yasodhara and Dorothy Truong Pak Cheung Chan, Angeline Yasodhara and Dorothy Truong
  
  Objective: Serum protein electrophoresis (SPE) is commonly used to detect and quantify monoclonal immunoglobulins/components (MC). SPE resolves serum proteins into 5 or 6 major fractions, including albumin. A split or double albumin band in SPE is called bisalbuminemia or alloalbuminemia, a condition caused by genetic or acquired changes. Although isolated cases of bisalbuminemia have been reported in patients with monoclonal gammopathy (MG), there has been no study linking the two statistically or pathophysiologically. The objective of this study is, thus, to determine if bisalbuminemia is significantly associated with MG, and hence to provide value justification for its reporting in SPE. Methods: We conducted a retrospective study reviewing over 55,800 consecutive serum protein electrophoretograms for bisalbuminemia between June 2005 and O.. View More»
  

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