Journal of Pollution Effects & Control
Open Access
ISSN: 2375-4397
ISSN: 2375-4397
Anifowoshe AT
Nigeria
Research Article
Genotoxicity of Titanium Dioxide Nanoparticles using the Mouse Bone Marrow Micronucleus and Sperm Morphology Assays
Author(s): Bakare AA, Udoakang AJ, Anifowoshe AT, Fadoju OM, Ogunsuyi OI, Alabi OA, Alimba CG and Oyeyemi IT
Bakare AA, Udoakang AJ, Anifowoshe AT, Fadoju OM, Ogunsuyi OI, Alabi OA, Alimba CG and Oyeyemi IT
Titanium dioxide nanoparticles (TiO2-NPs) have recently been of public health and scientific concern due to their widespread use in industrial and household applications. However, there is limited information concerning its in vivo cytogenotoxicity. In this study, the cytogenotoxic effects of TiO2-NPs on the somatic tissue using the mouse bone marrow micronucleus (MN) assay and on reproductive tissue using the mouse sperm morphology assay and testicular histopathology were investigated. Five concentrations of 9.38, 18.75, 37.50, 75.00 and 150.00 mg/kg bwt were administered intraperitoneally at 0.5 mL/mouse to mice for five and ten consecutive days in the MN assay; and for five consecutive days in the sperm morphology assay. Double distilled water and cyclophosphamide (20 mg/kg bwt) served as negative and positive controls, respectively. A significant (p<0.05) incre.. View More»
DOI:
10.4172/2375-4397.1000156