Journal of Hepatology and Gastrointestinal disorders
Open Access

Annalisa Capuano

Publications

• Research Article
  Liver Injury due to Amoxicillin vs. Amoxicillin/Clavulanate: A Subgroup Analysis of a Drug-Induced Liver Injury Case-Control Study in Italy
  Author(s): Monia Donati, Domenico Motola, Roberto Leone, Ugo Moretti, Giovanna Stoppa, Elena Arzenton, Maria Carmela Lenti, Roberto Bonaiuti, Alessandro Mugelli, Alfredo Vannacci, Concetta Rafaniello, Liberata Sportiello, Annalisa Capuano, Oscar Bortolami and Alberto Vaccheri Monia Donati, Domenico Motola, Roberto Leone, Ugo Moretti, Giovanna Stoppa, Elena Arzenton, Maria Carmela Lenti, Roberto Bonaiuti, Alessandro Mugelli, Alfredo Vannacci, Concetta Rafaniello, Liberata Sportiello, Annalisa Capuano, Oscar Bortolami and Alberto Vaccheri
  
  Objective: Several studies showed that amoxicillin plus clavulanic acid (co-amoxiclav) is one of the most common agents associated to serious Drug Induced Liver Injury (DILI). We estimated the risk of acute serious DILI associated with amoxicillin alone compared with co-amoxiclav, through a multicenter case-control study carried out in nine Italian hospitals from October 2010 to January 2014. Methods: Cases were adults, with a diagnosis of acute liver injury. Controls presented acute clinical disorders, not related to chronic conditions and not involving the liver. Adjusted Odds Ratio (ORs) with 95% CI were calculated initially with a bivariate and then multivariate analysis. Results: We analysed 179 cases matched to 1770 controls. Seven cases were exposed to amoxicillin (adjusted OR 1.69, 95% CI 0.72-3.98) and 22 .. View More»
  DOI: 10.4172/2475-3181.1000143

  Abstract PDF

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