Lupus: Open Access
Open Access
ISSN: 2684-1630
+44 1300 500008
ISSN: 2684-1630
+44 1300 500008
Antonella Afeltra
Italy
Review Article
The Complex Role of Leptin in SLE: Is Leptin A Key Link between Metabolic Syndrome, Accelerated Atherosclerosis and Autoimmunity?
Author(s): Domenico PE Margiotta, Marta Vadacca, Luca Navarini, Fabio Basta and Antonella AfeltraDomenico PE Margiotta, Marta Vadacca, Luca Navarini, Fabio Basta and Antonella Afeltra
Adipokines discovery opened a new research field that investigates the interface and the relationship between immune response, nutrition, and metabolism. Leptin is the first adipokine discovered and exerts a wide spectrum of biologic function such as control of food intake and energy expenditure, modulation of insulin sensitivity, regulation of neuro-endocrine system and activation of immunity. Leptin involvement is described in many autoimmune diseases. In SLE, leptin seems playing a complex role, linking metabolic syndrome, atherosclerosis, and autoimmune disease activity... View More»
DOI:
10.35248/2684-1630.16.1.107