Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Antonio Ceriello
IRCCS, MultiMedica,
Via Milanese, 300, Sesto, San Giovanni (MI)
Italy
Research Article
In Vitro Study Examining the Activity of Vildagliptin and Sitagliptin against Hyperglycemia-Induced Effects in Human Umbilical Vein Endothelial Cells
Author(s): Lucia La Sala, Stefano Genovese and Antonio CerielloLucia La Sala, Stefano Genovese and Antonio Ceriello
Background: In diabetes, endothelial dysfunction leads to vascular complications that negatively impact on patient outcome. Endothelial dysfunction may be mediated by hyperglycemia-induced oxidative stress, protein kinase C-β (PKC-β) activation and endoplasmic reticulum (ER) stress. As these events are antagonized by glucagon-like peptide-1 (GLP-1), a therapeutic strategy able to increase GLP-1 levels may prevent endothelial impairment, providing a clinical benefit to diabetic patients.
Aim of the present study was to test the capacity of dipeptidyl peptidase-4 (DPP-4) inhibitors, known to increase GLP-1 levels, to contrast hyperglycemia-induced effects in human umbilical vein endothelial cells (HUVECs).
Methods: HUVECs grown for 21 days under conditions of continuous normal or high glucose (NG and HG, respectively) were .. View More»
DOI:
10.4172/2155-9880.1000494