Journal of Depression and Anxiety
Open Access
ISSN: 2167-1044
ISSN: 2167-1044
Aparna Sharma
Tanzania
Research Article
Serum BDNF: A Potential Biomarker for Major Depressive Disorder and Antidepressant Response Prediction
Author(s): Angelos Halaris, Aparna Sharma, Edwin Meresh, Ghanshyam Pandey, Robin Kang, Brandon Hage, Brittany Garlenski and James Sinacore
Angelos Halaris, Aparna Sharma, Edwin Meresh, Ghanshyam Pandey, Robin Kang, Brandon Hage, Brittany Garlenski and James Sinacore
Background: The neurotrophin hypothesis of depression emphasizes the role of down-regulation of Brainderived Neurotrophic Factor (BDNF) in the pathophysiology of Major Depressive Disorder (MDD). Patients with MDD may have reduced serum BDNF levels and treatment with antidepressants may stimulate the expression of BDNF resulting in normalization of BDNF after successful treatment. Objective: To determine whether serum BDNF in MDD patients is lower than in healthy control (HC) subjects, whether all MDD patients show lower than normal levels and whether MDD patients with comparatively higher BDNF levels will respond better to antidepressant therapy. Method: Ninety medically healthy outpatients diagnosed with MDD were enrolled in one of two studies. In Study-1 patients were treated with escitalopram and in Study-2 with quetiapine. The main outcome measure was the 17-item Hamilton Depressi.. View More»
DOI:
10.4172/2167-1044.1000179