Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Are-Sun You
Republic of Korea
Research Article
Pulmonary Proteome and Protein Networks in Response to the Herbicide
Paraquat in Rats
Author(s): Il Kyu Cho, Mihye Jeong, Are-Sun You, Kyung Hun Park and Qing X Li
Il Kyu Cho, Mihye Jeong, Are-Sun You, Kyung Hun Park and Qing X Li
Paraquat (PQ) has been one of the most widely used herbicides in the world. PQ, when ingested, is toxic to humans and may cause acute respiratory distress syndrome. To investigate molecular perturbation in lung tissues caused by PQ, Sprague Dawley male rats were fed with PQ at a dose of 25 mg/kg body weight for 20 times in four weeks. The effects of PQ on cellular processes and biological pathways were investigated by analyzing proteome in the lung tissues in comparison with the control. Among the detected proteins, 321 and 254 proteins were overrepresented and under-represented, respectively, in the PQ-exposed rat lung tissues in comparison with the no PQ control. All over- and under-represented proteins were subjected to Ingenuity Pathway Analysis to create 25 biological networks and 38 pathways of interacting protein clusters. Over-represented proteins were involved in the C-jun-am.. View More»
DOI:
10.4172/jpb.1000354