Gynecology & Obstetrics
Open Access

Arnault Joal

Publications

• Case Report
  Maternal Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes Syndrome and Neonatal Magnesium Toxicity: A Case Report
  Author(s): Bénédicte Le Tinier, Kuntheavy Ing Lorenzini, Arnaud Joal and Begoña Martinez De Tejada Bénédicte Le Tinier, Kuntheavy Ing Lorenzini, Arnaud Joal and Begoña Martinez De Tejada
  
  Introduction: Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome is a progressive disorder associated with neurologic, cardiac, neuromuscular, hepatic, metabolic and gastrointestinal dysfunction, including potential anesthetic and obstetrical complications. Increased susceptibility to drugs in patient with MELAS syndrome can be due to drug-induced mitochondrial toxicity and/or decreased elimination. We present here a case of severe neonatal magnesium sulfate toxicity in the context of MELAS syndrome. Case presentation: A 43-year-old, gravida 5, para-5 (4 prior vaginal deliveries and the current cesarean section) woman with asymptomatic MELAS syndrome (carrier of the genetic variant NC_012920.1: m3243A>G in 20% of the mitochondrial DNA) was given intravenous magnesium sulfate for preeclampsia shortly.. View More»
  DOI: 10.4172/2161-0932.1000429

  Abstract PDF

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