Journal of Applied Pharmacy
Open Access

Asheful Latif

Publications

• Research Article
  A Comparative Study of Dissolution Profile and Its Validation for Levonorgestrel and Ethinylestradiol Combined Oral Doses Form Tablet
  Author(s): Md Didarul Islam, T.M. Mohiuddin, Asheful Latif, Md. Mynul Hassan, M. Mehedi Hasan and Papia HaqueMd Didarul Islam, T.M. Mohiuddin, Asheful Latif, Md. Mynul Hassan, M. Mehedi Hasan and Papia Haque
  
  Dissolution is one of the most important characteristics of a drug directly effect on the drug absorption and bioavailability. The dissolution of Levonorgestrel and Ethinylestradiol from oral dosage forms at different dissolution media: Acetate, HCl, Water and Phosphate have been studied by using an RP-HPLC method. Dissolution of Levonorgestrel after 60 min in acetate, HCl, water and phosphate were 98, 95, 97 and 98% respectively. For Ethinylestradiol dissolution after 60 min at indicated media were 91, 82, 92 and 93% respectively. From that point HCl media has been rejected. Difference (f1) and similarity (f2) factor of test sample has been calculated comparing with Microgynon 30 mg Tablet (reference dose) and dissimilarity was found in water and phosphate media and can reject both of them. Only acetate media has been found the best option among four dissolution media for simultaneou.. View More»
  

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