Chemotherapy: Open Access
Open Access

Asit K Jha

Publications

• Case Report
  Langerhans Cell Sarcoma: Treatment with Dose-adjusted EPOCH
  Author(s): Abhisek Swaika, Neha Sood, David M Menke, Asit K Jha and Sikander Ailawadhi Abhisek Swaika, Neha Sood, David M Menke, Asit K Jha and Sikander Ailawadhi
  
  Background: Langerhans cell sarcoma (LCS) is a rare malignancy with no specific defined treatment strategy.Chemotherapy is the preferred option in cases with systemic involvement, though no consensus exists on thepreferred regimen. Case: A sixty-six year old male presented with advanced-stage LCS involving the bone marrow (BM) and spleen. Immunohistochemical analysis of the BM-sample confirmed the diagnosis of LCS. The patient was treated withchemotherapy utilizing dose-adjusted Etoposide, Prednisone, Vincristine, Cyclophosphamide and Doxorubicin (DAEPOCH). The patient achieved complete remission and was able to tolerate the entire course (6 cycles) of chemotherapy with continued response at 10 months. Conclusion: Due to the rarity of the disease no standard treatment modality exists; most successful treatment options described are anecdotal reports. Due to the paucity of such data an.. View More»
  DOI: 10.4172/2167-7700.1000155

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