ISSN: 2161-1149 (Printed)
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Assogba M
Benin
Research Article
Genetic Susceptibility to Rheumatoid Arthritis in West African Patients: Correlation with Rheumatoid Factor, Anticitrullinated Protein Antibody and Radiological Damage
Author(s): Zomalheto Z, Assogba M, Avohou G, Azombakin J and Laleye AZomalheto Z, Assogba M, Avohou G, Azombakin J and Laleye A
Background: Rheumatoïd arthritis (RA) is characterized by a multifactorial aetiology and a complex genetic background, with the major histocompatibility complex (MHC) region playing a major role.
Aim of the work: To detect the genetic susceptibility to RA in Benin population.
Patients and Methods: A prospective case-control study was conducted from December 2015 to December 2016. The selected unrelated patients suffered from RA according to the American College of Rheumatology (ACR) criteria. We genotyped HLA-DRB1*01, HLADRB1*04 and HLA-B locus between 52 west african patients with RA and 48 unrelated controls to study the susceptibility of the genes to RA among Patients. Low-resolution genotyping for HLA B and HLADRB1 alleles was performed using Polymerase Chain Reaction and Sequence-Specific Primers (PCR-SSP.. View More»
DOI:
10.4172/2329-8731.1000221