Journal of Women's Health Care
Open Access
ISSN: 2167-0420
ISSN: 2167-0420
August S Bassani
Tanzania
Research Article
Evaluation of the in vitro Human Skin Percutaneous Absorption of Progesterone
in Versabase® Using the Franz Skin Finite Dose Model
Author(s): August S Bassani, Daniel Banov and Maria Carvalho
August S Bassani, Daniel Banov and Maria Carvalho
Women may benefit from hormone replacement therapy to alleviate undesirable menopausal symptoms such as hot flashes, disruption of sleep and fatigue. Transdermal hormone replacement therapy consists in the delivery of hormones through the skin and into the blood stream, avoiding gastrointestinal drug absorption difficulties and the first pass effect. Transdermal compounded medications may be customized to meet the individual needs of women by changing the hormones used, the respective concentrations and the medicine’s formulation. Two compounded medications were prepared for progesterone 50 mg/g, as follows: Progesterone in VersaBase® Cream and progesterone in VersaBase® Cream Gel. The purpose of this study is to determine the in vitro human skin percutaneous absorption of progesterone for both test formulations. The Franz Skin Finite Dose Model was the methodology used .. View More»
DOI:
10.4172/2167-0420.1000384